Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L.

نویسندگان

  • R Schoental
  • M E Fowler
  • A Coady
چکیده

One adenoma and one adenocarcinoma of the islet cells and one adenoma of the exocrine pancreas were found in 3 out of 15 rats given a single dose (500 to 1500 mg/kg body weight) of pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey (Boraginaceae), tarweed, a plant known to cause livestock losses from liver damage in the United States. Among rats treated with Heliotropium supinum L. (Boraginaceae), a hepatotoxic Ethiopian plant (known to be used in East Africa by women after childbirth), one islet cell adenoma was found in one out of six rats that were given a single dose of its crude alkaloidal fraction (300 mg/kg body weight) and one adenocarcinoma in one out of two rats that had the dried plant H. supinum in their diet for 1 month. The five rats with pancreatic tumors were 26 to 31.5 months old when killed. Such tumors have not been noticed among control rats of similar ages.

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منابع مشابه

Pyrrolizidine alkaloids from Heliotropium transoxanum Bunge

Background and objectives: The plants belonging to the genus Heliotropium L. (Boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (PAs). In the present study, we have investigated the PAs of the aerial parts of Heliotropium transoxanum Bunge, a perennial species native to Iran. Methods: Silica gel column chromatography and silica gel PTLC were applied ...

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"Blinding" of shoots and a leaf gall in Amsinckia intermedia induced by Anguina amsinckia (Steiner and Scott, 1934) (Nemata, Tylenchidae), with a note on the absence of a rachis in A. amsinckia.

"Blinding" and a leaf gall induced on Amsinckia intermedia Fisch. and Mey. by Anguina amsinckia (Steiner and Scott) are described. A. amsinckia induced blinding by galling the terminal apical meristem of its host. The leaf gall was formed by a ventral curling of the distal edge of the leaf. The absence of a rachis in the ovary of A. amsinckia is noted.

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Evaluation of Hepatotoxicity of Common Doses of Decoction of Echium Amoenum Fisch and C.A. Mey in Rats

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Evaluation of Hepatotoxicity of Common Doses of Decoction of Echium Amoenum Fisch and C.A. Mey in Rats

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عنوان ژورنال:
  • Cancer research

دوره 30 8  شماره 

صفحات  -

تاریخ انتشار 1970